Abstract Background To lagoon (snes contribute to the knowledge of coleopteran cytogenetics, especially with respect to the genomic content of B chromosomes, we analyzed the composition and organization of repetitive DNA sequences in the Coprophanaeus cyanescens karyotype.We used conventional staining and the application of fluorescence in situ hyb
The transcriptional repressor domain of Gli3 is intrinsically disordered.
The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway.Gli3 contains a repressor domain in its N-terminus from residue G106 to E236.In this study we have characterized the intracellular structure of the Gli3 repressor domain using a combined bioinformatics and experimental app
Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial
Introduction Patients with a first venous thromboembolism (VTE) are at risk of recurrence.Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding.It is still uncertain whether patients with an intermediate recurrence risk or with a high lagoon (snes recurrence and high ble